Cell totipotency: molecular features, induction, and maintenance
نویسندگان
چکیده
منابع مشابه
Cell totipotency: molecular features, induction, and maintenance.
In mammals, pluripotent stem cells can give rise to every cell type of embryonic lineage, and hold great potential in regenerative medicine and disease modeling. Guided by the mechanism underlying pluripotency, pluripotent stem cells have been successfully induced through manipulating the transcriptional and epigenetic networks of various differentiated cell types. However, the factors that con...
متن کاملThe molecular underpinnings of totipotency.
Embryonic stem (ES) cells are characterized by their functional potency and capacity to self-renew in culture. Historically, ES cells have been defined as pluripotent, able to make the embryonic but not the extraembryonic lineages (such as the yolk sac and the placenta). The functional capacity of ES cells has been judged based on their ability to contribute to all somatic lineages when they ar...
متن کاملThe induction and maintenance of T cell anergy.
While the "true" role of T cell anergy in promoting peripheral tolerance continues to be debated, it is clear that studying the various models of anergy have led to important insight in terms of understanding the pathways and molecules responsible for T cell activation and inhibition. This review will examine our current understanding of CD4+ T cell anergy. In particular, it will focus on the s...
متن کاملTotipotency/pluripotency and patentability.
UNLABELLED In their article entitled " COMMENTARY Is totipotency of a human cell a sufficient reason to exclude its patentability under the European law" (Stem Cells 2007;25:3026-3028), K.T. Vrtovec and B. Vrtovec conclude that arguments based on differentiation potential should not be an obstacle to patenting human embryonic stem cells (and related cells referred to as totipotent or pluripot...
متن کاملTotipotency, pluripotency and nuclear reprogramming.
Mammalian development commences with the totipotent zygote which is capable of developing into all the specialized cells that make up the adult animal. As development unfolds, cells of the early embryo proliferate and differentiate into the first two lineages, the pluripotent inner cell mass and the trophectoderm. Pluripotent cells can be isolated, adapted and propagated indefinitely in vitro i...
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ژورنال
عنوان ژورنال: National Science Review
سال: 2015
ISSN: 2053-714X,2095-5138
DOI: 10.1093/nsr/nwv009